最近我们在研究免疫抑制剂—醋酸氢化考的松对免疫系统的影响时,发现氢考能深刻地抑制免疫应答。例如给小鼠一次皮下接种5mg 氢考,可引起血液中单核细胞和淋巴细胞大幅度下降,中性粒细胞先低后高,由 PHA 刺激的淋巴细胞增殖试验极度减低等。这种情况可持续至少2周。与此同时,小鼠对条件致病菌如白色念珠菌的易感性显著升高。为了探讨免疫抑制剂是否会抑 Recently, we studied the immunosuppressant - hydrocortisone acetate on the immune system, found that hydrogen test can profoundly suppress the immune response. For example, once a mouse was subcutaneously inoculated with 5 mg hydrogen test, the blood mononuclear cells and lymphocytes could be greatly reduced, the neutrophils low and then the high, and the PHA-stimulated lymphocyte proliferation test was extremely reduced. This situation can last at least 2 weeks. In the meantime, mice have a significantly increased susceptibility to opportunistic pathogens such as Candida albicans. In order to investigate whether immunosuppressants will be suppressed