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用酶联免疫吸附测试法检测了７例成人牙周炎（ＡＰ）患者全口拔牙前及拔牙后１、２、３、１２及１８个月的血清抗牙龈卟啉菌（Ｐｇ）抗体水平的变化，并与６名牙周健康成人血清进行对照。结果表明，７例ＡＰ患者全口拔牙后血清抗ＰｇＩｇＧ抗体均逐月下降且明显低于拔牙前水平，但在拔牙后１８个月时仍明显高于对照组水平。血清抗体水平基本以相近似的速率下降，其中拔牙后１个月时的下降率较低。其下降率与牙周病各临床指数之间未显示明显的相关性。拔牙前的抗体水平与全口存留牙的深牙周袋率之间呈正相关趋势。本研究结果提示，在Ｐｇ感染去除后，机体对Ｐｇ抗原所产生的抗体逐渐下降，以牙周病患者血清抗ＰＧＩｇＧ水平作为该菌感染存在的诊断指标之一，值得进一步研究。
Serum anti-Pg antibody levels in 7 adult patients with periodontitis (AP) before full tooth extraction and at 1, 2, 3, 12 and 18 months after tooth extraction were measured by enzyme-linked immunosorbent assay Changes and compared with 6 periodontal healthy adult sera. The results showed that serum anti-PgIgG antibody in 7 AP patients decreased month by month and was significantly lower than that before tooth extraction, but still significantly higher than that of the control group 18 months after tooth extraction. Serum antibody levels decreased at approximately similar rates, with a lower rate of decline at 1 month after tooth extraction. The rate of decline and periodontal disease between the clinical index showed no significant correlation. There was a positive correlation between the antibody level before extraction and the rate of deep periodontal pockets of intact teeth. The results suggest that after the removal of Pg infection, the body of antibodies against Pg antigen gradually decreased to the periodontal disease serum anti-PGIgG levels as one of the diagnosis of the existence of the bacterial infection indicators worth further study.