论文部分内容阅读
Human immunodeficiency virus type 1 (HIV-1)is the principal causative agent of AIDS which is threatening human health. The most important antigen of HIV1 is the viral envelope glycoprotein, gp160. The mature form of the HIV-1 gp160 is made up of two major regions:the extracellular (gq120) and the transmembrane (gp41) domains. The gp120 binds with high affinity to CD4. he cellular receptor for HIV-1, and antibodies that prevent the CD4-gq120 interaction are able to block HIV-1 infection. A principal neutralizing deter-
The most important antigen of HIV1 is the viral envelope glycoprotein, gp160. The mature form of the HIV-1 gp160 is made up of The gp120 binds with high affinity to CD4. he cellular receptor for HIV-1, and antibodies that prevent the CD4-gq120 interaction are able to block HIV-1 infection. A principal neutralizing deter-