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目的观察生长抑素 (施他宁 )对重症急性胰腺炎的治疗效果及其对重症急性胰腺炎患者血浆内毒素和TNF α水平的影响。方法 6 2例重症急性胰腺炎患者随机分为治疗组和对照组 ,治疗组采用施他宁治疗 ,对照组给予一般常规治疗 ,于第 1、3、5、7天抽血测定血浆内毒素和TNF α。结果重症急性胰腺炎患者入院第 1天的血浆内毒素和TNF α水平明显高于健康人 ;治疗组患者血浆内毒素和TNF α水平下降速度明显快于对照组。结论重症急性胰腺炎患者早期均存在不同程度的内毒素血症及血浆TNF α水平升高 ,生长抑素治疗重症急性胰腺炎疗效肯定 ,治疗组患者血浆内毒素和TNF α水平下降速度均明显快于对照组。
Objective To observe the effect of somatostatin (Sitatlon) on the treatment of severe acute pancreatitis and its effect on plasma endotoxin and TNFα levels in patients with severe acute pancreatitis. Methods Sixty-two patients with severe acute pancreatitis were randomly divided into treatment group and control group. The treatment group was treated with shitamine, while the control group was given conventional treatment. Blood samples were collected for plasma endotoxin and TNF α. Results The levels of plasma endotoxin and TNFα on the first day of hospital admission in patients with severe acute pancreatitis were significantly higher than those in healthy controls. The plasma endotoxin and TNFα levels in the treatment group decreased significantly faster than those in the control group. Conclusions All patients with severe acute pancreatitis have different levels of endotoxemia and plasma TNFα levels in the early stage, and the efficacy of somatostatin in treating severe acute pancreatitis is positive. The plasma endotoxin and TNFα levels decline significantly in the treatment group In the control group.