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6名老年与6名年轻健康志愿者肌内注射丁胺卡那霉素7.5mg/kg后,老年组经1.04h达血药峰浓度23.54±2.98μg/ml,年轻组经0.99h达峰浓度20.77±2.38μg/ml,老年组与年轻组7h后血浆中浓度分别为5.24μg/ml和1.97μg/ml,按开放一室模型拟合后算得,消除半衰期分别为2.31±0.56h和1.58±0.28h(P<0.05),表观分布容积分别为0.235±0.026L/kg和0.239±0.010L/kg,老年组和年轻组24h尿排泄原药分别为74.3±12.2%和75.4±8.1%,肾清除率分别为61.93±24.30ml/min和84.63±25.41ml/min。结果表明,丁胺卡那霉素老年人消除比年轻人要慢。
6 old and 6 young healthy volunteers intramuscular injection of amikacin 7.5mg / kg, the elderly group reached peak blood drug concentration of 23.54 ± 2.98μg / ml 1.04h, the young group reached a peak concentration of 0.99h 20.77 ± 2.38μg / ml. After 7h, the plasma concentrations in the elderly group and the young group were 5.24μg / ml and 1.97μg / ml, respectively, and the half-lives were 2.31 ± 0.56h and 1.58 ± 0.28h (P <0.05). The apparent volume of distribution was 0.235 ± 0.026L / kg and 0.239 ± 0.010L / kg, respectively. The urinary excretion of 24 hours in old group and young group were 74.3 ± 12.2% and 75.4 ± 8.1% Kidney clearance rates were 61.93 ± 24.30 ml / min and 84.63 ± 25.41 ml / min, respectively. The results show that, amikacin elderly eliminate more slowly than young people.