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目的 :探讨胃粘膜中热休克蛋白 72 (HSP72 )、幽门螺杆菌 (Hp)的热休克蛋白 6 0 (又称 HSP B)在 Hp感染中的病理生理意义。方法 :用免疫组织化学方法和 Western blotting法检测 Hp(+ )组和 Hp(- )组的十二指肠球部溃疡患者胃窦粘膜中 HSP72 、HSP B的表达情况。结果 :Hp(+ )组 HSP72 的表达明显高于 Hp(- )组 (P <0 .0 5 ) ,Hp(+ )组 HSP B的表达显著高于 Hp(- )组 (P <0 .0 1)。结论 :Hp自身可表达 HSP B作为其致病因子 ;Hp又可诱导胃粘膜表达 HSP72 介导胃粘膜的细胞保护机制。
Objective: To investigate the pathophysiological significance of heat shock protein-60 (HSP) and Helicobacter pylori (Hp) heat shock protein 60 (Hsp) in gastric mucosa in Hp infection. Methods: Immunohistochemistry and Western blotting were used to detect the expression of HSP72 and HSP B in antral mucosa of patients with duodenal ulcer in Hp (+) and Hp (-) groups. Results: The expression of HSP72 in Hp (+) group was significantly higher than that in Hp (-) group (P <0.05), and the expression of HSP B in Hp (+) group was significantly higher than that in Hp (-) group 1). Conclusion: Hp itself can express HSP B as its virulence factor; Hp can induce gastric mucosa expression HSP72-mediated cellular protective mechanism of gastric mucosa.