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目的探讨老年性胰腺癌局部晚期放化疗的临床疗效,并观察与C反应蛋白(CRP)、白蛋白及血红蛋白(Hb)的相关性。方法选择老年性局部晚期胰腺癌患者112例,并进行放化疗,年龄≥65岁。均在治疗前、后清晨采血并测定CRP、白蛋白和Hb。结果 112例患者中49例生存期低于6个月,63例≥6个月。<6个月的患者CRP高于≥6个月患者(P<0.05);<6个月的患者白蛋白和Hb均低于≥6个月患者(P<0.05)。治疗前和治疗后<20 mg/L CRP患者生存期分别高于≥20 mg/L CRP患者(P<0.05);治疗前白蛋白<30 g/L者和Hb<90 g/L者生存期分别均低于白蛋白≥25 g/L者和Hb≥90 g/L者(P<0.05)。治疗后白蛋白<30 g/L者和Hb<90 g/L者生存期分别均低于白蛋白≥30 g/L者和Hb≥90 g/L者(P<0.05)。治疗前后Logistic分析显示,CRP、白蛋白和Hb与生存期均有相关性(P<0.05)。放化疗后CRP高于治疗前(P<0.05);白蛋白和Hb均低于治疗前(P<0.05)。结论老年胰腺癌放化疗前后血清中均CRP明显升高,白蛋白和Hb下降,生存期与白蛋白、血红蛋白呈正相关,与CRP呈负相关。
Objective To investigate the clinical efficacy of locally advanced chemoradiation in the treatment of senile pancreatic cancer and observe its correlation with C-reactive protein (CRP), albumin and hemoglobin (Hb). Methods One hundred and twelve elderly patients with locally advanced pancreatic cancer were selected and treated with radiochemotherapy and chemotherapy, with a mean age of 65 years. Blood samples were collected before and after the treatment and were measured for CRP, albumin and Hb. Results Of the 112 patients, 49 patients had a survival of less than 6 months and 63 patients ≥6 months. Patients with CRP at 6 months had a higher CRP than those at 6 months (P <0.05). Patients with albumin and Hb at 6 months had a lower CRP than 6 months (P <0.05). Survival of patients with CRP <20 mg / L before and after treatment was significantly higher than those with CRP ≥ 20 mg / L (P <0.05), pre-treatment albumin <30 g / L and Hb <90 g / L Respectively, lower than those with albumin ≥25 g / L and Hb≥90 g / L (P <0.05). The survival time of patients with albumin <30 g / L and Hb <90 g / L after treatment were lower than those with albumin ≥30 g / L and Hb≥90 g / L respectively (P <0.05). Logistic analysis before and after treatment showed that there was a correlation between CRP, albumin and Hb and survival (P <0.05). The CRP level after radiotherapy and chemotherapy was higher than before treatment (P <0.05); albumin and Hb were lower than before treatment (P <0.05). Conclusions Both CRP and serum albumin levels in serum of elderly patients with pancreatic cancer before and after radiotherapy and chemotherapy are significantly higher than those of patients with chronic pancreatic cancer. The serum levels of albumin and hemoglobin are positively correlated with the survival time and negatively correlated with CRP.