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为了研究Norplant~(R)Ⅰ(内含左旋十八甲基炔诺酮)是否对人体有致突变作用,我们采用SCE技术分别对11名埋植 Norplant~(R)Ⅰ妇女和11名正常未埋植Norplant~(R)Ⅰ妇女外周血淋巴细胞进行了SCE检测,结果埋药组妇女与对照组妇女的每个细胞SCE平均值分别为5.42±0.18、4.20±0.16。两组妇女的SCE平均值经统计学处理(U检验),埋药组与对照组之间有显著性差异(P<0.05)。根据本实验的初步结果提示,长期埋植Norplant~(R)Ⅰ妇女的淋巴细胞SCE平均值增高。
In order to study whether norplant ~ (R) Ⅰ (containing levododecaeno norethindrone) has a mutagenic effect on human body, we used SCE technique to evaluate the effect of Norplant ~ (Ⅰ) Peripheral blood lymphocytes from Norplant ~ (Ⅰ) women were screened by SCE. The results showed that the mean value of SCE in each cell of women in embedded group and control group were 5.42 ± 0.18 and 4.20 ± 0.16, respectively. The mean SCE scores of the two groups of women were statistically analyzed (U test), there was a significant difference between the drug-buried group and the control group (P <0.05). According to preliminary results of this experiment, mean values of lymphocyte SCE in Norplant ~ (R) Ⅰ women who were implanted long-term were higher.