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目的:探讨活络散治疗颞下颌关节后区疼痛治疗疗效。方法:选取2014年1月—2015年5月于医院口腔科诊治的颞下颌关节后区疼痛患者73例,根据随机数字表法随机分为两组:对照组36例,行临床常规疗法治疗;实验组37例,在与对照组相同的临床常规治疗基础上加用活络散予以治疗,检测两组患者Friction颞下颌关节指数、血清基质金属蛋白酶-2(MMP-2)、羟脯氨酸(Hyp)和不良反应的变化,进而对两种治疗方法的临床疗效进行对比分析。结果:与对照组比较,实验组患者血清MMP-2、Hyp水平较低(P<0.05),DI、PI、CMI指数水平较低(P<0.05);实验组总有效率较高(P<0.05),实验组不良反应发生率较低(P<0.05)。结论:活络散对颞下颌关节后区疼痛患者治疗据有较好的临床疗效,且能有效降低患者血清MMP-2、Hpy、Friction颞下颌关节指数水平,对临床治疗颞下颌关节后区疼痛具有重要意义。
Objective: To investigate the curative effect of Huoshaosan in the treatment of pain in the posterior region of temporomandibular joint. Methods: Totally 73 patients with temporomandibular joint pain in the hospital from January 2014 to May 2015 were randomly divided into two groups according to the random number table: control group, 36 cases were treated with routine therapy; In the experimental group, 37 cases were treated with active radix and scattered for the same routine treatment as the control group. The Friction temporomandibular joint index, serum matrix metalloproteinase-2 (MMP-2), hydroxyproline Hyp) and adverse reactions, and then compare the clinical efficacy of the two treatment methods. Results: Compared with the control group, the levels of serum MMP-2 and Hyp in the experimental group were lower (P <0.05), and the indexes of DI, PI and CMI were lower (P <0.05) 0.05). The incidence of adverse reactions in the experimental group was lower (P <0.05). CONCLUSION: Huoluosan has better clinical curative effect on patients with pain in the posterior region of temporomandibular joint and can effectively reduce the level of serum MMP-2, Hpy and Friction temporomandibular joint index Significance.