A CFD method is used to numerically predict the hydrodynamic forces and moments acting on a ship passing through a lock with a constant speed. By solving the RANS equations in combination with the RNG k-e turbulence model, the unsteady viscous flow around the ship is simulated and the hydrodynamic forces and moments acting on the ship are calculated. UDF is com-piled to define the ship motion. Meanwhile, grid regeneration is dealt with by using the dynamic mesh method and sliding interface technique. Under the assumption of low ship speed, the effects of free surface elevation are neglected in the numerical simulation. A bulk carrier ship model is taken as an example for the numerical study. The numerical results are presented and compared with the available experimental results. By analyzing the numerical results obtained for locks with different configurations, the influences of approach wall configuration, lock configuration symmetry and lock chamber breadth on the hydrodynamic forces and moments are demonstrated. The numerical method applied in this paper can qualitatively predict the ship-lock hydrodynamic interaction and pro-vide certain guidance on lock design.