百草枯(Paraquat,PQ)是一种非选择性有机杂环类物质,与土壤接触后迅速分解,无残留毒性,对环境无害。PQ进入人体后,能被迅速吸收,其中大部分在12~24h内经肾脏以原型排除。中毒机制复杂,目前认为主要涉及氧化损伤、炎症反应、细胞凋亡及基因异常表达等。PQ中毒具有极高的死亡率〔1〕,这使得急性PQ中毒治疗仍是一个重要的医 Paraquat (Paraquat, PQ) is a non-selective organic heterocyclic material that rapidly decomposes upon contact with soil and has no residual toxicity and is not harmful to the environment. PQ into the body, can be quickly absorbed, most of them within 12 ~ 24h by the kidneys to exclude the prototype. Poisoning mechanism is complex, currently considered mainly related to oxidative damage, inflammatory response, apoptosis and abnormal gene expression. PQ poisoning has a very high mortality 〔1〕, which makes the treatment of acute PQ poisoning is still an important medical