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近二十年来随着内分泌领域的进展,人们对维生素D的代谢产物及其生物学特性有了更深入的认识。目前已公认1,25(OH)_2D_3是一种活性类固醇激素。并认为1,25(OH)_2D_3的受体(VDR)不仅存于经典的靶组织(小肠、骨、甲状旁腺、肾脏),而且还存在于视网膜、胰腺、垂体、肌肉、睾丸、卵巢、脑、骨髓等许多组织;人的单核细胞,激活的T细胞,B细胞和许多肿瘤细胞也有VDR。1,25(OH)_2D_3不仅作为调解钙磷代谢的中心环节在防治佝偻病、骨软化方面具有重要作用,而且在调节免疫功能,抑制肿瘤生长、调节细胞
With the progress of the field of endocrine in the past two decades, people have a deeper understanding of the metabolites of vitamin D and their biological characteristics. Has now been recognized 1,25 (OH) _2D_3 is an active steroid hormone. The receptors of 1,25 (OH) _2D_3 were not only found in the classic target tissues (small intestine, bone, parathyroid, kidney) but also in the retina, pancreas, pituitary, muscle, testis, ovary, Brain, bone marrow and many other tissues; human monocytes, activated T cells, B cells and many tumor cells also have VDR. 1,25 (OH) _2D_3 not only plays an important role in mediating the metabolism of calcium and phosphorus, but also plays an important role in the prevention and treatment of rickets and osteomalacia. It regulates immune function, inhibits tumor growth,