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目的:观察四物汤对应用促红细胞生成素的癌性贫血患者D-二聚体(D-D)水平的影响,探究四物汤对患者的血瘀证/高凝状态的影响。方法:选择47例肺癌合并癌性贫血的患者,根据患者是否服用中药分为研究组24例和对照组23例,并设健康对照组20例。对照组单独应用促红细胞生成素(EPO),研究组在此基础上加用中药四物汤,比较两组2周期治疗后有效率及D-二聚体含量的变化。结果:治疗量周期后研究组纠正贫血有效率高于对照组,比较有统计学意义(P<0.05);治疗前后两组患者D-二聚体均较健康对照组高,有统计学意义(P<0.05);对照组和研究组治疗前比较无统计学意义,治疗后研究组患者D-二聚体低于对照组,差异有统计学意义(P<0.05)。结论:四物汤有助于改善癌性贫血,改善患者的血瘀证/高凝状态,降低血栓风险。
Objective: To observe the effect of Siwu Tang on D-dimer (D-D) level in patients with anemia of erythropoietin and to explore the influence of Siwu Tang on blood stasis syndrome / hypercoagulable state. Methods: Forty-seven patients with lung cancer with cancer anemia were divided into study group (24 cases) and control group (23 cases) according to whether the patients took traditional Chinese medicine (TCM) and 20 healthy control group. In the control group, erythropoietin (EPO) alone was used. On the basis of this study, the research group added Chinese Siji Decoction to compare the changes of the effective rate and D-dimer after two cycles of treatment. Results: The correct rate of anemia in the study group after treatment was higher than that of the control group (P <0.05). The D-dimer in both groups before and after treatment was significantly higher than that in the healthy control group (P <0.05) P <0.05). There was no significant difference between the control group and the study group before treatment. After treatment, the D-dimer in the study group was lower than that in the control group (P <0.05). Conclusion: Siwu Decoction can help to improve the cancerous anemia, improve the blood stasis syndrome / hypercoagulable state and reduce the risk of thrombosis.