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为了观察替吉奥联合香菇多糖治疗老年晚期胃癌的临床疗效和不良反应,选取74例经病理确诊的老年晚期胃癌患者随机分组,实验组38例采用替吉奥80mg/(m2.d),分早晚2次口服,连续口服4周,休息2周,6周为1个周期;同期给予香菇多糖,每周2次,1mg/次,持续应用4周,休息2周,6周为1个周期。对照组36例,仅口服单药替吉奥(具体剂量同上);化疗>2个周期评价疗效。74例患者全部可以评价疗效,试验组38例患者中,CR 0例,PR 14例,SD 15例,PD 9例,有效率为36.8%,疾病控制率为76.3%。对照组36例患者中,CR 0例,PR 11例,SD 14例,PD 11例,有效率为30.6%,疾病控制率为69.4%。两组有效率及疾病控制率比较差异无统计学意义,P>0.05;白细胞减少、贫血、恶心呕吐发生率比较差异有统计学意义,P<0.05;两组病例Ⅲ～Ⅳ度不良反应发生率分别为5.3%和27.8%,差异有统计学意义,P<0.05。大部分不良反应在Ⅰ～Ⅱ度,且患者耐受良好。初步研究结果提示,替吉奥联合香菇多糖治疗老年晚期胃癌近期疗效确切,不良反应轻,应用方便。
In order to observe the clinical efficacy and adverse reactions of TIGO combined with lentinan in the treatment of elderly patients with advanced gastric cancer, 74 patients with pathologically diagnosed advanced gastric cancer were randomly divided into two groups: 38 patients in the experimental group were treated with 80 mg / (m2.d) Morning and evening 2 times orally, continuous oral administration for 4 weeks, rest for 2 weeks, 6 weeks for a cycle; lentinan given at the same period twice a week, 1mg / time, continuous application of 4 weeks, rest for 2 weeks, 6 weeks for a cycle . The control group of 36 patients, only oral single for Gio (specific dose above); chemotherapy> 2 cycles to evaluate the curative effect. Of the 38 patients in the experimental group, CR 0, PR 14, SD 15 and PD 9 cases, the effective rate was 36.8% and the disease control rate was 76.3%. Of the 36 patients in the control group, CR 0, PR 11, SD 14, and PD 11 had an effective rate of 30.6% and a disease control rate of 69.4%. There was no significant difference between the two groups in the effective rate and the disease control rate, P> 0.05; the incidence of leukopenia, anemia and nausea and vomiting were significantly different (P <0.05); The incidence of Ⅲ ~ Ⅳdegree of adverse reactions Respectively, 5.3% and 27.8%, the difference was statistically significant, P <0.05. Most of the adverse reactions in Ⅰ ~ Ⅱ degrees, and patients were well tolerated. Preliminary results suggest that for the treatment of elderly patients with advanced leukemia with Gogol combined polysaccharides recent curative effect, adverse reactions, easy to use.