Because uncertainty factors inevitably exist under multidisciplinary design environment, a hierarchical multidisciplinary robust optimization design based on response surface is proposed. The method constructs optimization model of subsystem level and system level to coordinate the coupling among subsystems, and also the response surface based on the artificial neural network is introduced to provide information for system level optimization tool to maintain the independence of subsystems, i.e. to realize multidisciplinary parallel design. The application case of electrical packaging demonstrates that reasonable robust optimum solution can be yielded and it is a potential and efficient multi-disciplinary robust optimization approach. Because uncertainty factors inevitably exist under multidisciplinary design environment, a hierarchical multidisciplinary robust optimization design based on response surface is proposed. The method constructs optimization model of subsystem level and system level to coordinate the coupling among subsystems, and also the response surface based on the artificial neural network is introduced to provide information for system level optimization tool to maintain the independence of subsystems, ie to realize multidisciplinary parallel design. The application case of electrical packaging demonstrates that reasonably robust optimum solution can be yielded and it is a potential and efficient multi- disciplinary robust optimization approach.