多发性硬化(Multiple sclerosis,MS)是一种中枢神经系统(CNS)脱髓鞘性疾病,然而近来许多文献报道其可以合并有周围神经系统(PNS)的损害。最近,谢淑萍等报道了国内首例,由病理证实合并有周围神经脱髓鞘改变的脊髓型MS。本文就MS合并PNS损害的临床特点、病理及电生理学改变、及其可能发病机理作一综述。 Multiple sclerosis (MS) is a demyelinating disease of the central nervous system (CNS), however, many recent reports have reported that it may be associated with damage to the peripheral nervous system (PNS). Recently, Xie Shuping and other reports of the first case of China, confirmed by pathology combined with peripheral nerve demyelination of spinal cord MS. This article reviews the clinical features, pathological and electrophysiological changes of MS combined with PNS and its possible pathogenesis.