论文部分内容阅读
目的:探讨不同中药对递增负荷游泳大鼠血红蛋白、血尿素氮及自由基代谢的影响。方法:Wistar大鼠61只,随机分为四组:正常对照组(NC组)12只、运动对照组(EC组)17只、运动+人参组(EP组)16只、运动+辽东楤木组(EA组)16只,采用6周递增负荷游泳训练方案,最后一次训练结束,随机剔除多余大鼠,24小时后,取样。测定血红蛋白、血尿素氮及血清丙二醛(MDA)的含量、血清超氧化物歧化酶(SOD)和谷胱甘肽过氧化物酶(GSH-Px)的活性。结果:(1)与NC组相比,EC组大鼠血尿素氮、血清MDA含量显著增加(P<0.01),血清SOD和GSH-Px活性、血红蛋白含量显著下降(P<0.01)。(2)与EC组相比,EP组和EA组大鼠血尿素氮、血清MDA含量均显著下降(P<0.01),血清SOD和GSH-Px活性、血红蛋白含量均显著增高(P<0.01)。结论:辽东楤木和人参可以提高6周递增负荷游泳后大鼠血红蛋白的含量、使血尿素氮含量下降、减少运动源性氧自由基的产生,起到保护抗氧化酶活性的作用,有助于运动后疲劳的恢复。
Objective: To investigate the effects of different traditional Chinese medicines on hemoglobin, blood urea nitrogen and free radical metabolism in swimming rats with increasing load. Methods: Sixty - one Wistar rats were randomly divided into four groups: control group (NC group), control group (EC group), exercise + + ginseng group (EP group), exercise + Twenty-six rats in group (EA group) received a six-week incremental load swimming training program. After the last training, redundant rats were randomly excluded and sampled 24 hours later. The levels of hemoglobin, blood urea nitrogen and serum malondialdehyde (MDA), serum superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) were measured. Results: (1) Compared with NC group, the levels of blood urea nitrogen and serum MDA increased significantly in EC group (P <0.01), while the activity of SOD and GSH-Px and the content of hemoglobin in EC group decreased significantly (P <0.01). (2) Compared with EC group, the content of blood urea nitrogen and serum MDA in EP group and EA group decreased significantly (P <0.01), and the activities of SOD and GSH-Px, hemoglobin in serum increased significantly (P <0.01) . Conclusion: Alnus japonica and ginseng can increase hemoglobin content of rats after 6 weeks of incremental load swimming, decrease the content of blood urea nitrogen, decrease the production of exercise-derived oxygen free radicals, and play an important role in the protection of antioxidant enzymes. Recovery from fatigue after exercise.