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探讨白细胞素６（ＩＬ－６）、肿瘤坏死因子（ＴＮＦ）及可溶性白细胞介素２受体（ｓＩＬ－２Ｒ）在脑梗塞发病中的作用及临床意义。方法：采用双抗体夹心ＥＬＩＳＡ法对４６例脑梗塞患者血清ＩＬ－６、ＴＮＦ及ｓＩＬ－２Ｒ水平同时进行了检测。结果：脑梗塞组急性期血清ＩＬ－６、ＴＮＦ及ｓＩＬ－２Ｒ水平变化与脑梗塞容积大小密切相关，恢复期血清ＩＬ－６、ＴＮＦ及ｓＩＬ－２Ｒ显著降低。结论：ＩＬ－６、ＴＮＦ及ｓＩＬ－２Ｒ参予了脑梗塞发生后病理变化过程，检测血清ＩＬ－６、ＴＮＦ及ＳＩＬ－２Ｒ对判定脑梗塞容积大小有一定的临床意义。
To investigate the role and clinical significance of interleukin 6 (IL-6), tumor necrosis factor (TNF) and soluble interleukin 2 receptor (sIL-2R) in the pathogenesis of cerebral infarction. Methods: Serum levels of IL-6, TNF and sIL-2R in 46 patients with cerebral infarction were detected by double antibody sandwich ELISA. Results: The changes of serum IL-6, TNF and sIL-2R in acute stage of cerebral infarction were closely related to the volume of cerebral infarction. The levels of IL-6, TNF and sIL-2R in convalescent phase were significantly decreased. CONCLUSION: IL-6, TNF and sIL-2R are involved in pathological changes after cerebral infarction. Detecting the serum levels of IL-6, TNF and SIL-2R have certain clinical significance in judging the volume of cerebral infarction.