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大鼠经饮水连续染铅（醋酸铅１５００ｍｇ／Ｌ蒸馏水）。分别在第１、２、４、６、８周末处死动物，取肾脏进行脂质过氧化相关指标及铅、锌、铜含量测定。结果表明，铅使丙二醛的生成量显著增加，且不受还原性谷胱甘肽含量的影响。超氧物歧化物酶活力表现为先受抑后升高再正常的变化过程，与组织中锌含量先降低后正常的状况一致。提示：铅可能通过取代酶活性中心的锌而抑制其活力，进而引起脂质过氧化。
Rats continuously lead by drinking water (lead acetate 1500mg / L distilled water). Animals were sacrificed at the end of the 1st, 2nd, 4th, 6th and 8th week respectively, and the kidneys were taken for lipid peroxidation related indexes and determination of lead, zinc and copper contents. The results showed that lead significantly increased the formation of malondialdehyde and was not affected by the content of reduced glutathione. The activity of superoxide dismutase (SOD) was first increased and then normalized by inhibition, which was in accordance with the normal condition after the zinc content in the tissue first decreased. Hint: Lead may inhibit lipid peroxidation by displacing zinc from its active site.