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女性尿道的原发性透明细胞腺癌是一种罕见的组织学变异,目前仅见报道8例.泌尿生殖道的非肾透明细胞腺癌很少见,但多见于女性,文献报道2例男性患者;其中一例发生于膀胱,一例发生于腹膜后。女性患者可发生于卵巢、阔韧带、阴道、宫颈及子宫。未证实尿道肿瘤与女性雌激素疗法有关,但雌激素疗法可与阴道和宫颈的透明细胞腺癌同时存在。尿道透明细胞腺癌的典型光镜特征是有许多大片而相连的细胞,胞浆透明、空泡样变,常含有大量糖
Female urethral primary clear cell adenocarcinoma is a rare histological variation, only 8 cases reported so far .Urogenital tract of non-renal clear cell adenocarcinoma is rare, but more common in women, reported in two cases of male patients One case occurred in the bladder and one in the retroperitoneum. Female patients can occur in the ovary, broad ligament, vagina, cervix and uterus. Urethral tumor is not confirmed with female estrogen therapy, but estrogen therapy and vaginal and cervical clear cell adenocarcinoma co-exist. Urethra clear cell adenocarcinoma of the typical light microscopy features are many large and connected cells, cytoplasm transparent, vacuolar degeneration, often containing a lot of sugar