AIM:IBD is a systemic disease associated with a largenumber of extraintestinal manifestations (EIMs).Our aimwas to determine the prevalence of EIMs in a large IBDcohort in Veszprem Province in a 25-year follow-up study.METHODS:Eight hundred and seventy-three IBD patientswere enrolled (ulcerative colitis/UC/:619,m/f:317/302,mean age at presentation:38.3 years,average diseaseduration:11.2 years;Crohn’s disease/CD/:254,m/f:125/129,mean age at presentation:32.5 years,average diseaseduration:9.2 years).Intestinal,extraintestinal signs andlaboratory tests were monitored regularly.Any alterationsuggesting an EIMs was investigated by a specialist.RESULTS:A total of 21.3% of patients with IBD had EIM(UC:15.0%,CD:36.6%).Age at presentation did not affectthe likelihood of EIM.Prevalence of EIMs was higher in womenand in CD,ocular complications and primary sclerosingcholangitis (PSC) were more frequent in UC.In UC there wasan increased tendency of EIM in patients with a more extensivedisease.Joint complications were more frequent in CD(22.4% vsUC 10.2%,P<0.01).In UC positive family historyincreased the risk of joint complications (OR:3.63).In CD thefrequency of type-1 peripheral arthritis was increased inpatients with penetrating disease (P=0.028).PSC was presentin 1.6% in UC and 0.8% in CD.Dermatological complicationswere present in 3.8% in UC and 10.2% in CD,the rate ofocular complications was around 3% in both diseases.Rarecomplications were glomerulonephritis,autoimmune hemolyticanaemia and celiac disease.CONCLUSION:Prevalence of EIM in Hungarian IBD patientsis in concordance with data from Western countries.Thehigh number of EIM supports a role for complex follow-upin these patients. AIM: IBD is a systemic disease associated with large numbers of extraintestinal manifestations (EIMs). Our aim was to determine the prevalence of EIMs in a large IBD cohort in Veszprem Province in a 25-year follow-up study. METHODS: Eight hundred and seventy- three IBD patients were enrolled (ulcerative colitis / UC /: 619, m / f: 317/302, mean age at presentation: 38.3 years, average disease duration: 11.2 years; Crohn’s disease / CD /: 254, m / f: 125/129 , mean age at presentation: 32.5 years, average disease duration: 9.2 years) .Intestinal, extraintestinal signs and laboratory tests were monitored regularly. A prior alterationsuggesting an EIMs was investigated by a specialist.RESULTS: A total of 21.3% of patients with IBD had EIM ( UC: 15.0%, CD: 36.6%). Age at presentation did not affect the likelihood of EIM. Prevalence of EIMs was higher in women and in CD, ocular complications and primary sclerosing cholangitis (PSC) were more frequent in UC. UC there was increased tendency of EIM in patients with a more extensive disease. Joint complications were more frequent in CD (22.4% vsUC 10.2%, P <0.01) .In UC positive family historyincreased the risk of joint complications (OR: 3.63). In CD the frequency of type-1 peripheral arthritis was increased in patients with penetrating disease P = 0.028) .PSC was present in 1.6% in UC and 0.8% in CD. Dermatological complications present in 3.8% in UC and 10.2% in CD, the rate ofocular complications was around 3% in both diseases. Other complications were glomerulonephritis, autoimmune hemolyticanaemia and celiac disease. CONCLUSION: Prevalence of EIM in Hungarian IBD patients with concordance with data from Western countries. The high number of EIM supports a role for complex follow-up in these patients.