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目的探讨血浆蛋白Z(Protein Z,PZ)水平与急性缺血性脑卒中(Acute ischemic stroke,AIS)发病的关系。方法采用病例-对照的研究方法,随机选取88例急性缺血性脑卒中患者及同期84例体检健康者。AIS患者均为急性期(发病后1~3d)取静脉血。以酶联免疫吸附法(ELISA)检测各组中血浆中PZ的含量。根据头部核磁共振(MRI)表现将A工S患者分为两组:皮质动脉卒中组和穿通动脉卒中组。结果急性缺血性脑卒中患者血浆PZ水平明显高于健康对照组(p<0.01)。其中穿通动脉卒中组血浆PZ水平明显低于皮质动脉卒中组(p<0.05),而与对照组差异无显著性(p>0.05)。结论血浆PZ水平明显增高可能是缺血性脑卒中重要的危险因素,提示血浆PZ水平增高可能在皮质动脉卒中发病中起到独立的作用。
Objective To investigate the relationship between the level of protein Z (PZ) and the pathogenesis of acute ischemic stroke (AIS). Methods A case-control study was conducted in which 88 patients with acute ischemic stroke and 84 healthy subjects were randomly selected. AIS patients are acute (1 ~ 3d after onset) to take venous blood. Plasma PZ levels in each group were detected by enzyme-linked immunosorbent assay (ELISA). A workers were divided into two groups based on head MRI: cortical stroke group and perforating artery stroke group. Results Plasma PZ levels in acute ischemic stroke patients were significantly higher than those in healthy controls (p <0.01). The level of plasma PZ in stroke group was significantly lower than that in cortical artery stroke group (p <0.05), but not significantly different from that in control group (p> 0.05). Conclusion Plasma PZ levels may be an important risk factor for ischemic stroke, suggesting that increased plasma PZ levels may play an independent role in the pathogenesis of cortical arterial stroke.