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目的：研究社会环境及给药时刻对小鼠阿米卡星代谢的影响．方法：小鼠按饲养环境：隔离饲养（Ｉ）或集体饲养（Ａ）及给药时间：日中（Ｄ）及午夜（Ｎ）随机分为：Ｉ－Ｄ，Ｉ－Ｎ，Ａ－Ｄ，Ａ－Ｎ４组．饲养４周后于Ｄ（１３∶００）或Ｎ（０１∶００）ｓｃ阿米卡星１５ｍｇ·ｋｇ－１，测定给药后其血浆浓度，以开放一室模型拟合并计算有关药代动力学参数．结果：Ａ－Ｎ组阿米卡星清除率较Ａ－Ｄ及Ｉ－Ｎ组增大，血浆半衰期变短，０－１小时血浆浓度时间曲线下面积（ＡＵＣ（０－１））较Ｉ－Ｎ组减少．隔离饲养两组（Ｉ－Ｄ，Ｉ－Ｎ）间药代动力学参数无显著差异．结论：社会环境及给药时刻均显著影响小鼠阿米卡星代谢动力学．
Objective: To study the influence of social environment and administration time on the metabolism of amikacin in mice. METHODS: Mice were randomly divided into I-D, I-N, A-D and I-N according to the feeding environment: isolated feeding or collective feeding and the administration time: A-N4 group. After 4 weeks of feeding, the plasma concentrations of the amikacin 15 mg · kg-1 were measured at D (13:00) or N (01:00) sc amikacin, and the pharmacokinetics were calculated by opening a one-compartment model Learning parameters. Results: The clearance rate of amikacin in A-N group was higher than that in A-D group and I-N group, and the plasma half-life was shortened. The area under the plasma concentration-time curve (AUC (0-1) -N group decreased. There was no significant difference in pharmacokinetic parameters between two groups (I-D, I-N). Conclusion: The social environment and administration time significantly affect the metabolism of amikacin in mice.