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目的 观察胰岛素在急性脑梗死治疗中的近期疗效 ,并讨论其机制。方法 对 1997～ 2 0 0 2年 86例非糖尿病的急性大脑中动脉梗死患者 ,随机分胰岛素组 44例和对照组 42例 ,对照组予常规治疗 ,胰岛素组在常规治疗基础上每日加用正规胰岛素 12～ 16U ,连续 7d ,观察血糖、胰岛素敏感性、欧洲脑卒中量表 (ESS)评分的变化。结果 两组间治疗前血糖、胰岛素敏感性、ESS评分均无差异。胰岛素组每日治疗后血糖均比对照组低 (P <0 0 1) ,但在正常范围内 ;14d时ESS评分胰岛素组比对照组高 (P <0 0 5)。结论 脑梗死急性期使用胰岛素使血糖维持在正常偏低水平 ,有助于神经功能的改善
Objective To observe the short-term efficacy of insulin in the treatment of acute cerebral infarction and to discuss its mechanism. Methods From 1997 to 2002, 86 non-diabetic patients with acute middle cerebral artery infarction were randomly divided into insulin group (44 cases) and control group (42 cases). The control group was given routine treatment. The insulin group was given routine daily Regular insulin 12 ~ 16U, continuous 7d, observed changes in blood glucose, insulin sensitivity, European Stroke Scale (ESS) score. Results There was no difference in blood glucose, insulin sensitivity and ESS score between the two groups before treatment. The daily blood glucose of the insulin group was lower than that of the control group (P <0.01), but within the normal range. On the 14th day, the ESS score of the insulin group was higher than that of the control group (P <0.05). Conclusions The use of insulin during the acute phase of cerebral infarction maintains the blood sugar at a normal low level and contributes to the improvement of neurological function