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心先安是环腺苷酸类药物,能进入有机体内发挥第二信使作用,从而对糖、脂肪代谢、核酸、蛋白质的合成调节,促进细胞生长分裂,增加心肌能量的利用,改善心脏功能起着重要的作用。据饶曼人等和陈锦明等的药理研究,心先安能明显降低狗的下肢、锥动脉、冠脉左旋支血管的阻力,对家兔急性心肌缺血具有良好的保护作用,并可增加离体豚鼠心脏的冠脉流量。此外又根据临床报道,心先安对病窦综合征、心绞痛、心衰和心肌病等疾病有良好的疗效(参见本专辑)。为此我室进一步探讨了心先安对体外正常心肌细胞和缺氧缺糖性心肌细他的搏动功能、乳酸脱氢酶(LDH)的变化,同时也初步观察了心先安对心肌细胞DNA合成的影响。
Cardioprotection is cyclic adenylate drugs, can enter the body to play a second messenger role, which sugar, fat metabolism, nucleic acid, protein synthesis regulation, promote cell growth and division, increase myocardial energy utilization, improve cardiac function Important role. According to Rao Man et al. And Chen Jinming and other pharmacological studies, Xin Xian An obviously reduces the dog’s lower extremity, conical artery, coronary artery left ventricular branch of the resistance, rabbit acute myocardial ischemia has a good protective effect, and can increase the distance Coronary flow in guinea pig heart. In addition, according to clinical reports, Xin Xian on the sick sinus syndrome, angina, heart failure and cardiomyopathy and other diseases have a good effect (see this album). To this end, I further explore the Xinxianxin in vitro normal cardiomyocytes and hypoxia-deficient cardiomyocytes pulsatility, lactate dehydrogenase (LDH) changes, but also preliminary observation of Xin Xian on myocardial cell DNA The impact of synthesis.