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由特异蛋白激酶和蛋白磷酸酶共同参与的蛋白质可逆性磷酸化是细胞生物学过程的重要调节机制,蛋白磷酸酶2A是真核生物主要的丝氨酸/苏氨酸蛋白磷酸酶,具有复杂的亚基构成,参与细胞的各种调节机制,包括信号转导途径、细胞周期进程、DNA复制、基因转录和蛋白质翻译等,其功能受多种层次的调控。最新的研究揭示了PP2A的三维晶体结构以及甲基化在全酶组合中的作用,同时对PP2A在细胞转化方面的功能与机制有了更深入的阐释。
Reversible phosphorylation of proteins, which is involved in the interaction of specific protein kinases and protein phosphatases, is an important regulatory mechanism of cellular biology. Protein phosphatase 2A is a major serine / threonine protein phosphatase of eukaryotes with complex subunits Constitute, participate in a variety of cell regulatory mechanisms, including signal transduction pathways, cell cycle progression, DNA replication, gene transcription and protein translation, its function is regulated by many levels. Recent studies reveal the three-dimensional crystal structure of PP2A and the role of methylation in the whole enzyme combination, as well as a more in-depth explanation of the function and mechanism of PP2A in cell transformation.