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骨髓移植目的有二:一是补充白血病及恶性淋巴瘤时为扑灭骨髓和淋巴结的肿瘤细胞使用强力化疗而减少的造血干细胞;二是为了把再生障碍性贫血及重症免疫功能不全患者量少质差的异常造血干细胞置换为正常的干细胞。本文仅就白血病、再生障碍性贫血、骨髓增生异常综合征、先天性免疫功能不全等疾患以外的血液系统疾患的骨髓移植适应证的进展做一论述。一、多发性骨髓瘤自1978年 Osserman 对多发性骨髓瘤首次试行骨髓移植以来,目前已开展了若干例同种或自体骨髓移植。据 Gahrton 统计,至1988年止,欧洲骨髓移植组织已进行了24例 HLA 适合的同种骨髓移植。其中因疾病复发和肾功衰竭
The purpose of bone marrow transplantation are twofold: First, leukemia and malignant lymphoma leukemia and malignant lymphoma to fight off the use of intensive chemotherapy to reduce the number of hematopoietic stem cells; the second is to reduce the amount of patients with aplastic anemia and immune deficiency dysfunction Of abnormal hematopoietic stem cells replaced by normal stem cells. This article only on the leukemia, aplastic anemia, myelodysplastic syndrome, congenital immune dysfunction and other diseases outside the blood system of bone marrow transplant indications for the progress made an account. Multiple myeloma Since the first trial of bone marrow transplantation in multiple myeloma by Osserman in 1978, several cases of allogeneic or autologous bone marrow transplantation have been performed. According to Gahrton statistics, up to 1988, the European bone marrow transplantation organization has carried out 24 HLA-identical allogeneic bone marrow transplantation. Which due to disease recurrence and renal failure