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近年有报道在hMG超排卵周期中,以GnRH增效剂(GnRHa)代替hCG,可能降低卵巢过度刺激综合征(OHSS)发生率;但因GnRHa对垂体的降调节及直接溶黄体作用,尽管补充孕酮仍约有18％黄体期过短。作者采用前瞻性自身对照方法,比较hMG/hCG方案与hMG/GnRH方案的疗效及并发症。
In recent years, it has been reported that in the hMG superovulation cycle, GnRH synergist (GnRHa) instead of hCG may reduce the incidence of ovarian hyperstimulation syndrome (OHSS); but because of GnRHa pituitary down regulation and the role of direct dissolution of the corpus luteum, although the supplement Progesterone is still about 18% of the luteal phase is too short. The authors used a prospective, self-controlled approach to compare the efficacy and complications of the hMG / hCG regimen with the hMG / GnRH regimen.