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目的探讨米索前列醇联合缩宫素预防剖宫产术后出血的临床效果。方法选择2010年5月~2011年5月,在我院产科住院行剖宫产术,有产后出血高危因素无规律宫缩的产妇200例,随机分为米索前列醇+缩宫素组和缩宫素组各100例,两组均于胎儿娩出后宫体注射缩宫素20iu,静脉滴注中加缩宫素20iu,观察组麻醉满意后,铺单前由麻醉医师给予米索前列醇400μg,经直肠置药,深至4~5cm,采用术中吸引器收集术中出血量及测量纱布计量出血量。术后2h采用称重方法计量出血量。结果观察组产后出血量及产后出血例数均明显小于对照组,术中及产后2h出血量两组差异有统计学意义(P<0.01)。结论米索前列醇直肠给药联合缩宫素预防剖宫产产后出血效果明显,且疗效可靠、应用简单、价格低廉、安全性高、不良反应轻,对减少剖宫产产后出血的发生,减少输血量,减少子宫切除,提高产妇生活质量,降低孕产妇死亡率均具有重要意义。
Objective To investigate the clinical effect of misoprostol combined with oxytocin in preventing bleeding after cesarean section. Methods From May 2010 to May 2011, 200 cases of cesarean section in obstetrics and gynecology hospital in our hospital with irregular contractions of high risk factors for postpartum hemorrhage were randomly divided into misoprostol + oxytocin group and Oxytocin group of 100 cases, both groups were injected into the uterus in the fetus after injection of oxytocin 20iu, intravenous infusion of oxytocin 20iu, the observation group was satisfied with anesthesia, the shop before the anesthesiologist given misoprostol 400μg , The rectal medicine, as deep as 4 ~ 5cm, the use of intraoperative aspiration to collect blood loss and measurement gauze bleeding. 2h after the method of weighing the amount of bleeding. Results The number of postpartum hemorrhage and postpartum hemorrhage in the observation group were significantly less than those in the control group. There was significant difference between the two groups in intraoperative and postpartum 2h bleeding (P <0.01). Conclusion The combination of misoprostol and oxytocin for preventing bleeding after cesarean section is effective and reliable. It has the advantages of simple application, low cost, high safety and light adverse reactions. It can reduce the incidence of bleeding after cesarean section and reduce Blood transfusion, reduce hysterectomy, improve the quality of life of pregnant women, reduce maternal mortality are of great significance.