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目的探讨胃癌组织中膜型基质金属蛋白酶2(MT2-MMP)的表达与肿瘤细胞增殖程度的相关性。方法免疫组化检测55例胃癌和11例癌旁正常组织中MT2-MMP蛋白及Ki-67的表达,分析MT2-MMP表达与患者临床病理特征及肿瘤细胞增殖程度的关系。结果 MT2-MMP蛋白在胃癌组织中的表达水平高于癌旁正常组织(P<0.05)。胃癌组织中MT2-MMP的表达水平和患者临床病理特征无明显相关性。淋巴结转移患者的MT2-MMP表达水平与Ki-67阳性细胞百分比呈显著正相关(P<0.05)。结论 MT2-MMP在胃癌组织中高表达,并与肿瘤细胞增殖有关。
Objective To investigate the relationship between the expression of membrane-type matrix metalloproteinase 2 (MT2-MMP) and the degree of tumor cell proliferation in gastric cancer. Methods The expressions of MT2-MMP and Ki-67 in 55 cases of gastric cancer and 11 cases of normal tissues were detected by immunohistochemistry. The relationship between the expression of MT2-MMP and the clinicopathological features and the degree of tumor cell proliferation was analyzed. Results MT2-MMP protein expression in gastric cancer tissue was higher than that in adjacent normal tissues (P <0.05). There was no significant correlation between MT2-MMP expression and clinicopathological features in gastric cancer. The level of MT2-MMP in patients with lymph node metastasis was positively correlated with the percentage of Ki-67 positive cells (P <0.05). Conclusion MT2-MMP is highly expressed in gastric cancer and is related to tumor cell proliferation.