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给大鼠连续7d(dl—d7)sc吲哚洛尔200μg/kg·d或甲氧乙心安12.5mg/kg·d,用荧光分光法测心肌及尿中NA及A的含量。在d2及d6吲哚洛尔分别使心肌中NA降到正常值的69％及19％(p<0.01),A的变化相仿。尿中NA在d2亦降低。停药后尿中NA反而比正常增多(p<0.001)。甲氧乙心安在d2使心肌中NA降低(p<0.01),d6时增多(p<0.01)。d2尿中NA增多,但停药后未见反跳现象。讨论了吲哚洛尔与甲氧乙心安对组胺中NA影响的差别,与吲哚洛尔的内在活性及甲氧乙心安的β_1选择性的关系。
Rats were dosed with either pindolol 200 μg / kg · d or metoprolol for 7 days (dl-d7) or 12.5 mg / kg · d respectively. The contents of NA and A in myocardium and urine were measured by spectrofluorometry. In d2 and d6, pindolol reduced the NA in myocardium to 69% and 19% of normal (p <0.01), respectively, and the changes in A were similar. NA in urine also decreased at d2. After stopping the urine NA but increased more than normal (p <0.001). Metoclopramide reduced the NA in myocardium at d2 (p <0.01) and increased at d6 (p <0.01). d2 urinary NA increased, but no rebound after stopping the phenomenon. The effects of pindolol and metoprolol on the NA in histamine were discussed, and their relationship with the intrinsic activity of pindolol and the beta - 1 selectivity of metformin were discussed.