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以烷化剂卡莫司汀(商品名Gliadel)浸渗的可生物降解的聚合物“糯米纸囊剂”已在美国上市,用于复发而需再次手术的多形恶性胶质瘤的局部治疗。体积为10分硬币大小的聚酐糯米纸囊剂被植入切除后留下的手术腔的后面。烷化剂的释放直接进入肿瘤区域而跨越血脑屏障。
Biodegradable polymer “Wafer” impregnated with the alkylating agent Carmustine (trade name Gliadel) has been marketed in the United States for the topical treatment of recurrent malignant multiforme glioblastoma . Polyanhydride wafers in 10-cent coin size were implanted behind the surgical cavity left after resection. The release of alkylating agents directly into the tumor area straddles the blood-brain barrier.