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目的 :研究细胞周期蛋白E有胃癌组织中的表达与细胞增殖活性及其它临床病理因素的关系。方法 :用免疫组织化学方法检测 40例胃癌组织中细胞周期蛋白E和Ki-6 7的表达。结果 :胃癌组织中细胞周期蛋白E和Ki-6 7表达阳性率分别为 45 %和 72 5 % ,在细胞周期蛋白E阳性胃癌中Ki-6 7阳性率明显高于细胞周期蛋白E阴性胃癌 (P <0 0 5 )。此外还发现细胞周期蛋白E在胃癌中的表达与肿瘤浸润深度、淋巴结转移和TNM分期密切相关 ( P <0 0 5 )。结论 :提示细胞周期蛋白E在胃癌中的表达与Ki-6 7的表达有关 ,并在肿瘤的进展中起一定作用
Objective: To study the relationship between the expression of cyclin E in gastric cancer tissues and cell proliferation activity and other clinicopathological factors. Methods : Immunohistochemistry was used to detect the expression of cyclin E and Ki-67 in 40 gastric cancer tissues. RESULTS: The positive rates of cyclin E and Ki-67 expression in gastric cancer tissues were 45% and 72.5%, respectively. The positive rate of Ki-67 in gastric cancer tissues was significantly higher than that of cyclin E-negative gastric cancers. P <0 0 5 ). In addition, it was also found that the expression of cyclin E in gastric cancer was closely related to the depth of tumor invasion, lymph node metastasis, and TNM stage (P < 0.05). Conclusions: It is suggested that the expression of cyclin E in gastric cancer is related to the expression of Ki-67 and plays a role in the progression of tumors.