论文部分内容阅读
给氧常用于治疗急性和慢性呼吸衰竭。在这些情况中,细菌感染常见。作者通过测定对气溶吸入的放射性同位素(~(32)磷)标记的金黄色葡萄球菌的灭活率和物理清除率,研究了在大气压力下,给予多种浓度(30～100％)的氧气对肺脏抗菌防御网的作用。在100％的氧气中,头48小时期间,宿主防御直线下降(与暴露时间成正比)。在暴露于100％的氧气72、96和120小时后,肺内细菌繁殖超过灭活。暴露于100％以下的氧浓度,宿主防御的降低与暴露的浓度和时间成正比,各种氧浓度和各种暴露时间(包括暴露于30％氧气24小时)对宿主防御均有明显削弱。间歇性暴露于100％氧气或连续暴露于60％以下的氧浓度,可发生适应性耐受性,减轻因中毒而引起
Oxygen is commonly used to treat acute and chronic respiratory failure. Bacterial infections are common in these situations. By measuring the inactivation rate and physical clearance rate of aerosolized radioactive isotope (~ (32) P) -induced Staphylococcus aureus, we studied the effects of various concentrations (30-100%) of The Role of Oxygen on Lung Antibacterial Defense Network. In 100% of oxygen, the host defense plummets during the first 48 hours (proportional to exposure time). After 72, 96, and 120 hours of exposure to 100% oxygen, bacterial growth in the lung exceeded inactivation. Exposure to oxygen concentrations below 100% decreases host defense in proportion to the concentration and time of exposure, and various concentrations of oxygen and various exposure times, including exposure to 30% oxygen for 24 hours, significantly diminish host defense. Intermittent exposure to 100% oxygen or continuous exposure to oxygen concentration below 60%, adaptive tolerance can occur to reduce the poisoning caused