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本文报道应用同位素放射免疫分析法测定哮喘患者血浆TXB_2 和6-酮-前列腺素F_(1α)(6-K-PG F_(1α))水平。对象:Ⅰ组为哮喘急性发作期患者12例(男7例,女5例,平均年龄35岁),本次哮喘发作在6小时以内,未用抗哮喘药物;Ⅱ组为临床缓解期患者15例(男10例,女5例,平均年龄32岁),均有典型哮喘发作史,但两周内无自觉症状,自动停药;Ⅲ组为正常对照组20例(男女各10例,平均年龄28岁)。结果:TXB_2 Ⅰ组明显高于Ⅱ、Ⅲ组,P<0.01;Ⅱ组也显著高于Ⅲ组,P<0.01;6-K-PGF_(1α)三组间
This article reports the determination of plasma TXB_2 and 6-keto-PGF 1α (6-K-PG F_ (1α)) levels in patients with asthma using radioimmunoassay. PARTICIPANTS: Group Ⅰ was 12 patients (7 males and 5 females, average age 35 years) in the acute exacerbation of asthma. The asthma attack was within 6 hours and no anti-asthma drugs were used. The patients in group Ⅱ were remission 15 Cases (10 males and 5 females, average age 32 years), have a history of typical asthma, but no symptoms within two weeks, automatic withdrawal; group Ⅲ was 20 cases of normal control group (10 males and 10 females, mean Age 28 years old). Results: The levels of TXB_2 in group TXB_2 were significantly higher than those in groups Ⅱ and Ⅲ (P <0.01), and those in group Ⅱ were significantly higher than those in group Ⅲ (P <0.01)