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目的观察阿托伐他汀对急性脑梗死患者颈动脉粥样硬化斑块的影响。方法选取医院收治的急性脑梗死患者86例,随机分为对照组和观察组,每组43例。对照组给予常规治疗,观察组在常规治疗基础上加用阿托伐他汀治疗。观察比较2组治疗前后血清总胆固醇(TC)、血清三酰甘油(TG)、血清低密度脂蛋白(LDL-C)、血清高密度脂蛋白(HDL-C)变化情况;观察比较2组治疗前后斑块面积、斑块数量及颈动脉内膜中层厚度(IMT)变化情况。结果治疗前,2组TC、TG、LDL-C、HDL-C数值比较差异无统计学意义(P>0.05);治疗后,2组除对照组TG值与治疗前比较差异无统计学意义(P>0.05)外,2组其他TC、LDL-C、HDL-C数值较治疗前均改善,且观察组改善情况优于对照组(P<0.01)。治疗后,观察组斑块面积、斑块数量以及颈动脉IMT数值均少于对照组(P<0.05)。结论阿托伐他汀在急性脑梗死患者治疗中具有极高的应用价值,效果显著,有利于阻止颈动脉粥样硬化斑块发展。
Objective To observe the effect of atorvastatin on carotid atherosclerotic plaques in patients with acute cerebral infarction. Methods Totally 86 patients with acute cerebral infarction admitted to hospital were randomly divided into control group and observation group with 43 cases in each group. The control group was given routine treatment, and the observation group was treated with atorvastatin on the basis of routine treatment. The levels of total cholesterol (TC), serum triglyceride (TG), serum low density lipoprotein (LDL-C) and serum high density lipoprotein (HDL-C) in two groups were observed and compared before and after treatment. Plaque area, plaque number and carotid artery intima-media thickness (IMT). Results Before treatment, there was no significant difference in TC, TG, LDL-C and HDL-C between the two groups (P> 0.05). After treatment, there was no significant difference between the two groups except the control group P> 0.05), the other TC, LDL-C and HDL-C values of two groups were improved than those before treatment, and the improvement of the observation group was better than that of the control group (P <0.01). After treatment, the area of plaque, the number of plaques and the carotid IMT in the observation group were less than those in the control group (P <0.05). Conclusions Atorvastatin is of great value in the treatment of patients with acute cerebral infarction. The effect of atorvastatin is significant and it is helpful to prevent the development of carotid atherosclerotic plaque.