论文部分内容阅读
目的观察激素替代治疗(HRT)对卵巢与宫颈恶性肿瘤预后的影响。方法1999年8月至2003年6月对广西医科大学肿瘤医院的31例卵巢恶性肿瘤和34例子宫颈癌患者术后或放疗后进行HRT,同时选择同期收治的年龄、临床期别和病理类型大致相同的44例卵巢恶性肿瘤和49例子宫颈癌作为对照。使用倍美力片或尼尔雌醇加安宫黄体酮作为HRT方法。采用Kaplan-Meier生存曲线Log-Rank分析法,COX比例风险模型,对随访数据进行分析。结果HRT和非HRT两组在各临床病理因素间相比较,差异无显著性(P>0·05)。HRT和非HRT两组妇科恶性肿瘤复发或转移病例间相比较,差异无显著性(P>0·05)。Kaplan-Meier生存曲线Log-Rank分析,两组患者的生存期比较差异无显著性(P>0·05)。经COX比例风险模型分析,HRT不是影响生育期卵巢恶性肿瘤和宫颈癌预后的因素。结论HRT对卵巢恶性肿瘤和宫颈癌的预后无明显不良影响。
Objective To observe the effect of hormone replacement therapy (HRT) on the prognosis of ovarian and cervical cancer. Methods From August 1999 to June 2003, 31 cases of ovarian cancer and 34 cases of cervical cancer from Guangxi Medical University Cancer Hospital were treated with HRT after operation or after radiotherapy. The patients’ age, clinical stage and pathological type The same 44 cases of ovarian cancer and 49 cases of cervical cancer as a control. Beometrile tablets or nilestriol plus medroxyprogesterone acetate were used as the HRT method. Kaplan-Meier survival curve Log-Rank analysis, COX proportional hazard model, the follow-up data were analyzed. Results There was no significant difference in each clinicopathological factors between HRT and non-HRT groups (P> 0.05). HRT and non-HRT gynecological malignant tumor recurrence or metastasis between the two cases, the difference was not significant (P> 0.05). Kaplan-Meier survival curve Log-Rank analysis showed no significant difference in survival between the two groups (P> 0.05). According to the COX proportional hazards model, HRT is not the factor that affects the prognosis of ovarian cancer and cervical cancer during the reproductive life. Conclusion HRT has no significant adverse effect on the prognosis of ovarian cancer and cervical cancer.