黑色素瘤原发于中枢神经系统者甚为罕见,目前国内报道不多,现将我院遇到的二例原发于脑与骨髓的黑色素瘤报道如下: 例1,男性,32岁,因腰痛伴双下肢进行性无力,运动障碍4个月,于1984年12月24日入院。体检:皮肤及粘膜未见黑色素痣,颅神经未发现异常,左下肢肌力Ⅳ级,右下肢肌力Ⅱ级,双下肢肌张力下降,腱反射消失,左提睾反射减弱,右侧消失。L_1平面以下痛觉消失,深感觉存在。血常规检查正常,柱管碘油造影提示骨髓圆锥受压,脑脊液蛋白292mg％。临床诊断为脊髓压迫症。于1985年1月10日在局麻下以T_(12)—L_1为中心行椎管探查术,术中见T_(10)—L_1硬脊膜外 Primary melanoma in the central nervous system is very rare, currently little domestic coverage, now our hospital encountered two cases of primary melanoma in the brain and bone marrow are reported as follows: Example 1, male, 32 years old, due to low back pain With bilateral lower extremity progressive weakness, dyskinesia 4 months, on December 24, 1984 admission. Physical examination: No melanoma was found in the skin and mucous membranes. No abnormalities were found in the cranial nerves. The left lower extremity muscle strength was grade Ⅳ, the right lower extremity muscle strength was grade Ⅱ, the lower extremity muscle tension was decreased, the tendon reflex disappeared, the left cremasteric reflex was weakened and the right disappeared. L_1 below the plane pain disappeared, deep feeling exists. Blood tests were normal, column tube lipiodol prompted bone marrow compression, cerebrospinal fluid protein 292mg%. Clinical diagnosis of spinal cord compression. On January 10, 1985 under local anesthesia to T_ (12) -L_1 center for spinal exploration, see T_ (10) -L_1 intraoperative epidural