微管不稳定蛋白Stathm in在细胞周期的不同阶段对微管动力平衡的调节发挥重要作用。多种恶性肿瘤中Stathm in都有高水平表达,抑制其表达可以干扰恶性细胞的细胞分裂。Stathm in的过表达可干扰紫杉醇与微管的结合,但增加长春碱类药物与微管的结合能力,临床用药时应予考虑。另外,Stathm in为肿瘤基因治疗提供了一个分子新靶点。腺病毒介导抗stathm in核酶治疗联合泰素药物治疗可能获得更强有力的抗增殖和抗肿瘤效应。 Microtubule-labile protein Stathm in plays an important role in the regulation of microtubule homeostasis at different stages of the cell cycle. Stathm in a variety of malignant tumors have high levels of expression, inhibition of its expression can interfere with malignant cell division. Stathm in overexpression can interfere with the combination of paclitaxel and microtubules, but increase the binding capacity of vinca alkaloids and microtubules, should be considered in clinical medication. In addition, Stathm in provides a new molecular target for tumor gene therapy. Adenovirus-mediated anti-stathm ribozyme therapy in combination with paclitaxel may result in a more potent anti-proliferative and anti-tumor effect.