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AN-488(Sanorex)[研制单位]サンド药品[研究阶段]申请中[商品名]Sanorex[用途]代谢用药[剂型]片剂[CAS]22232-71-9[化学名]5-p-chlorophenyl-5-hydrox-y-2,3-dihydro-5-H-imidazo(2,1-α]isoindole[开发概况]AN-488由Sandoz公司开发,在欧美各国市场上作为减肥药销售。其结构是三环类化合物,具有较好的减肥效果。1985年开始申请。现期望有可能作为糖尿病、高血压病所引起的肥胖患者的减肥治疗。MCI-5011(tritoqualine)[研制单位]三菱化成[研究阶段]申请中[商品名]Livalfa [用途]肝脏制剂[剂型]片剂[CAS]14504-73-5[化学名]7-amino-4,5,6-triethoxy-3-(5,6,7,8-tetrahydro-4-methoxy-6-methyl-1,3-dioxolo[4,5,-G]isoquinolin-5-5yl)ph-thalide[开发概况]MCI-5011首先作为抗变态反应药在欧洲上市。该药对肝损伤所需的肝细胞机能的修复有较好作用,三菱化成制药企业将作为肝脏用药进一步开发,是高效能用于肝细胞机能修复的药物,其副作用小。
AN-488 (Sanorex) [R & D Unit] サ ン ド Drugs [Stage of Study] Application [Trade name] Sanorex [Use] Metabolism [Formulation] Tablets [CAS] 22232-71-9 [Chemical name] 5-p-chlorophenyl -5-hydrox-y-2,3-dihydro-5-H-imidazo (2,1-α] isoindole [Development Overview] AN-488 was developed by Sandoz Company and is marketed as a diet- Is a tricyclic compound, has a good weight loss effect .Applied in 1985. It is expected to be possible as Diabetes, Hypertension caused by obesity in patients with weight loss treatment .MCI-5011 (Tritoqualine) [Development Unit] Mitsubishi Chemical [ Research phase] Application [Product name] Livalfa [Use] Liver preparation [Formulation] Tablet [CAS] 14504-73-5 [Chemical name] 7-amino-4,5,6-triethoxy-3- (5,6 , 7,8-tetrahydro-4-methoxy-6-methyl-1,3-dioxolo [4,5-G] isoquinolin-5-5yl) ph- thalide [Developmental profile] MCI-5011 was first used as an anti-allergic agent Marketed in Europe.The drug has a good effect on the repair of hepatic cells needed for liver injury, and Mitsubishi Chemical Pharmaceuticals will further develop the drug for the liver, which is a high-potency drug for the repair of liver cells with small side effects .