论文部分内容阅读
周围性神经病是指周围运动神经、感觉神经和自主神经系统损害。近年不时有关于替比夫定和干扰素联用致周围神经病的报道,其发生率为16.7%,发生时间为4.5个月。替比夫定与干扰素联用所致周围神经病表现为单神经损害或多神经损害,以感觉神经受损害为主。其诊断是依据临床表现、肌电图检查和神经传导速度检查的结果。由于替比夫定尚可引起肌病,故应注意肌病与周围神经病的鉴别。临床上应尽可能避免替比夫定与干扰素联用。一旦确定周围神经病为替比夫定与干扰素联用所致,两药应立即停用。
Peripheral neuropathy refers to the surrounding motor, sensory, and autonomic nervous system damage. In recent years, from time to time about the telbivudine and interferon associated with peripheral neuropathy was reported, the incidence was 16.7%, the occurrence time of 4.5 months. Telbivudine and interferon combined with peripheral neuropathy caused by single or polyneurous damage manifested as the main damage to the sensory nerve. The diagnosis is based on clinical manifestations, electromyography and nerve conduction velocity test results. Because telbivudine can still cause myopathy, it should be noted myopathy and peripheral neuropathy identification. As far as possible to avoid telbivudine and interferon should be used clinically. Once the determination of peripheral neuropathy is telbivudine combined with interferon, the two drugs should be immediately discontinued.