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至目前止,国内在用毛果芸香硷治疗青光眼仍以局部滴药为主要给药方法。总结滴药的缺点有:①结膜囊内药物浓度下降快,影响组织吸收;②因药物浓度下降快,浓度必须提高,眼及全身易发生毒性作用;③药物大部份从结膜囊溢出,造成浪费;④药物作用时间短暂,需频频滴药,费时费力。为此需寻求方便青光眼用药的新方法。40年代英国药典就记载有毛果芸香硷薄膜。60年因药膜工业的发展,已开始用于结膜囊,还将药物粉末与高分子聚合物拌匀制成膜剂用于临床。70年代药膜在
So far, the domestic use of pilocarpine in the treatment of glaucoma is still part of the main drug delivery method. Summarize the shortcomings of dropping drugs are: ① the drug concentration in conjunctival sac declines rapidly, affecting tissue absorption; ② due to drug concentration decreased rapidly, the concentration must be increased, eyes and body prone to toxic effects; ③ most of the drug overflow from the conjunctival sac, resulting in Waste; ④ short duration of medication, need frequent drops, time-consuming and laborious. To this end need to find a new method of glaucoma medication. British Pharmacopoeia in the 1940s documented pilocarpine base film. 60 years due to the development of the film industry, has begun to be used for conjunctival sac, but also the drug powder and polymer blend well into the film for clinical use. 70’s film in