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目的:探讨牛磺酸、维生素对高同型半胱氨酸血症(HHcy)兔动脉粥样硬化的干预作用。方法:采用高L-蛋氨酸饮食方法建立兔HHcy血症模型,补充牛磺酸、叶酸、Vit B6、Vit B12,8周,以正常家兔为对照,分别于实验0,4,8周检测各组血清同型半胱氨酸(Hcy)、丙二醛(MDA)、总胆固醇(TC)、甘油三酯(TG)、一氧化氮(NO)、血栓素B2(TXB2)含量和超氧化物岐化酶(SOD)活力,并通过血管超声观察腹主动脉血管病理变化。结果:模型组4周、8周时血清Hcy,MDA,TG,TC,ET,TXB2含量显著高于同期空白组(P<0.01,P<0.05),而NO含量、SOD活力则明显降低(P<0.01);牛磺酸和维生素组Hcy显著低于模型组(P<0.01),维生素组8周时与对照组无差异;MDA,TG,TC,ET,TXB2含量两干预组均显著低于模型组(P<0.01),而NO,SOD比模型组显著增高(P<0.01)。血管超声观察,模型组腹主动脉内膜明显增厚、血管平滑肌细胞增生,弹力纤维断裂、排列紊乱、有斑块形成;牛磺酸和维生素组血管内膜较光滑、结构排列整齐无斑块,与空白组比较无显著差异。结论:牛磺酸具有拮抗Hcy诱导的损伤效应,维生素加速Hcy代谢,抑制高Hcy导致的血管损害,二者均有延缓或阻止AS形成的作用。
Objective: To investigate the effect of taurine and vitamin on the atherosclerosis in hyperhomocysteinemia rabbits. Methods: The model of hyperlipemia in rabbits was established by high L-methionine diet. Taurine, folic acid, Vit B6 and Vit B12 were supplemented for 8 and 8 weeks respectively. The normal rabbits were used as control and tested at 0, 4 and 8 weeks The levels of serum homocysteine, malondialdehyde (MDA), total cholesterol (TC), triglyceride (TG), nitric oxide (NO), TXB2 and superoxide dismutase (SOD) activity, and observe the pathological changes of abdominal aorta by vascular ultrasound. Results: The levels of Hcy, MDA, TG, TC, ET and TXB2 in the model group were significantly higher than those in the blank control group at 4 weeks and 8 weeks (P <0.01, P <0.05) <0.01). Hcy in taurine and vitamin group was significantly lower than that in model group (P <0.01), there was no difference between vitamin group and control group at 8 weeks; MDA, TG, TC, ET, Model group (P <0.01), while NO and SOD were significantly higher than the model group (P <0.01). Vascular ultrasound showed that the intima of the abdominal aorta in the model group was thicker, the vascular smooth muscle cells were hyperplastic, the elastic fibers were disrupted and disordered, and the plaques were formed. The intima of the taurine and vitamin group was smooth and the structures were arranged neatly without plaque , No significant difference compared with the blank group. CONCLUSION: Taurine can antagonize the injury induced by Hcy. Vitamins accelerate Hcy metabolism and inhibit the vascular damage caused by high Hcy. Both of them have the effect of retarding or preventing AS formation.