论文部分内容阅读
间充质干细胞(mesenchymal stem cells,MSCs)是具有自我更新、多向分化和强可塑性的细胞,具有分化为血液、骨、软骨、脂肪、肌肉、表皮、上皮、神经等组织的潜能,受到再生医学研究的关注。目前已有研究表明将MSCs移植到多种损伤组织中都能改善损伤组织的功能。文章在简要回顾了低氧环境对MSCs增殖和分化的研究内容和有关理论争论基础上重点介绍了缺氧诱导因子(HIF)通路对MSCs增殖和分化的影响。文章阐述了低氧环境对MSCs向成骨,成软骨,成脂及成神经元方向分化的影响。由于人体组织内生理条件下的氧张力远远小于大气中的氧张力(21%),采用低氧培养MSCs的研究方法得出的结论将更加贴近实际MSCs在人体内的增殖、分化情况。因此研究MSCs在低氧张力环境中增殖、分化的能力将为MSCs能成功移植到体内并发挥作用提供保障。
Mesenchymal stem cells (MSCs) are cells with self-renewal, multidirectional differentiation and strong plasticity. They have the potential to differentiate into blood, bone, cartilage, fat, muscle, epidermis, epithelium, Medical research concerns. At present, studies have shown that transplantation of MSCs into a variety of damaged tissues can improve the function of damaged tissues. The article briefly reviews the hypoxic environment on the proliferation and differentiation of MSCs and related theoretical debate on the basis of the emphasis on hypoxia inducible factor (HIF) pathway on the proliferation and differentiation of MSCs. This article describes the effects of hypoxia on the differentiation of MSCs into osteogenic, chondrogenic, adipogenic and neuronal cells. Because the oxygen tension under physiological conditions in human tissues is far less than the oxygen tension (21%) in the atmosphere, the conclusion drawn by the research methods using hypoxic cultured MSCs will be closer to the actual proliferation and differentiation of MSCs in humans. Therefore, studying the ability of MSCs to proliferate and differentiate in hypoxia-tension environment will provide a guarantee for MSCs to be transplanted into the body and play their role.