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目的将Rh血型系统相容性输血应用在儿科输血中。方法采用微柱凝胶法,对本院2015年5月-2016年7月临床申请输血的患儿血液标本3 254例、献血者血液标本6 851例做ABO和Rh血型表型鉴定并将检测结果录入输血信息管理系统,经过电子比对筛选,共做4 493次交叉配血。结果本组输血患儿与本地献血者的Rh表型分布频律从高到低为CCDee:38.94%(1 267/3 254)vs 41.67%(2 855/6 851),Cc DEe:38.60%(1 256/3 254)vs35.50%(2 432/6 851),Cc Dee:9.25%(301/3 254)vs 9.56%(655/6 851),cc DEE:7.87%(256/3 254)vs 7.95%(545/6851),cc DEe:4.36%(142/3 254)vs 4.11%(282/6 851),CCDEe:0.34%(11/3 254)vs 0.63%(43/6 851)、cc Dee:0.40%(13/3 254)vs 0.31%(20/6 851)、Cc DEE:0.25%(8/3 254)vs 0.28%(19/6 851)、CCDEE:0(0/3 254)vs 0(0/6851)(P<0.05);在4 493次交叉配血中,有3 273次受血者和献血者Rh抗原表型一致,713次受血者与献血者抗原非一致性但是符合相容性输注,507次输血患儿的Rh表型与献血者的不相容,Rh系统抗原相容性输血比例达到88.72%(3 986/4 493)。结论采用Rh系统相容性输血可有效地预防输血患儿免疫抗体的产生;同时可方便快捷地满足Rh系统不规则抗体阳性患儿输血和重度高胆红素血症患儿换血对血源的需求。
Objective To apply Rh blood group compatible blood transfusion in pediatric blood transfusion. Methods The microcolumn gel method was used to analyze the blood samples of 3 254 blood transfusion patients from May 2015 to July 2016 in our hospital and 6 851 blood samples from blood donors for phenotypic identification of ABO and Rh blood type. The results were entered into the transfusion information management system and electronically matched and screened for a total of 4 493 crosses. Results The frequency distribution of Rh phenotype in children with transfusion and local blood donors from high to low was CCDee: 38.94% (1 267/3 254) vs 41.67% (2 855/6 851), Cc DEe: 38.60% ( 1 256/3 254) vs. 35.50% (2 432/6 851), Cc Dee: 9.25% (301/3 254) vs 9.56% (655/6 851), cc DEE: 7.87% (256/3 254) vs 7.95% (545/6851), cc DEe: 4.36% (142/3 254) vs 4.11% (282/6 851), CCDEe: 0.34% (11/3 254) vs 0.63% (43/6 851) cc Dee: 0.40% (13/3 254) vs. 0.31% (20/6 851), Cc DEE: 0.25% (8/3 254) vs 0.28% (19/6 851), CCDEE: 0 ) vs 0 (0/6851) (P <0.05). In the 4 493 crosses with blood, there were 3 273 blood donors and blood donors Rh antigen phenotype, 713 blood donors were not consistent with blood donors antigens However, consistent with compatible infusion, the Rh phenotype in 507 transfusions was incompatible with blood donors. The proportion of Rh compatible antigen-compatible transfused blood reached 88.72% (3 986/4 493). CONCLUSIONS: Rh-compatible blood transfusion can effectively prevent the generation of immune antibodies in children with transfusion and can quickly and easily meet the requirements of blood transfusion and severe hyperbilirubinemia in Rh-type irregular antibody-positive children demand.