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目的探讨应用加巴喷丁(gabapentin)治疗带状疱疹急性期神经痛的临床效果与安全性。方法带状疱疹急性期患者32例,随机分为安慰剂组和加巴喷丁组,每组16例,均给常规药物治疗,加巴喷丁组在此基础上给予口服加巴喷丁,剂量自300 mg/d起,根据服药后患者疼痛的缓解程度以及不良反应予以调整,每2d增加剂量1次,直至VAS≤3,然后以此剂量维持,疗程4周。分别于治疗前及治疗后1、2、4周采用视觉模拟评分(VAS)进行疼痛评估。结合24h疼痛持续时间和睡眠质量评分(QS)评定治疗效果。同时观察患者的不良反应。结果加巴喷丁组患者VAS评分、24h疼痛持续时间显著降低(P<0.01),睡眠状况也明显改善(P<0.01)。镇痛起效最低剂量为300 mg,1次/d,80%患者每日有效镇痛剂量在300～900 mg,日最大剂量达1200 mg。结论带状疱疹急性期应用加巴喷丁可显著缓解疱疹疼痛症状。
Objective To investigate the clinical efficacy and safety of gabapentin in the treatment of acute neuralgia of shingles. Methods Thirty-two patients with acute herpes zoster were randomly divided into placebo group and gabapentin group, 16 patients in each group were given conventional drug treatment. Gabapentin group was given gabapentin orally on the basis of 300 mg / d. After taking the patient’s pain relief and adverse reactions to be adjusted, increasing the dose every 2d 1, until VAS ≤ 3, and then maintained at this dose, the course of 4 weeks. Pain was assessed using visual analogue scale (VAS) before treatment and at 1, 2, and 4 weeks after treatment. The duration of pain and sleep quality score (QS) were used to evaluate the therapeutic effect. At the same time observe the adverse reactions in patients. Results In the gabapentin group, VAS score, 24h duration of pain decreased significantly (P <0.01), and sleep status also significantly improved (P <0.01). The lowest dose of analgesic onset is 300 mg, once a day, 80% of patients daily effective analgesic dose of 300 ~ 900 mg, maximum daily dose of 1200 mg. Conclusion The application of gabapentin in acute stage of herpes zoster can relieve herpes pain symptoms.