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目的探讨餐后高血糖与心血管危险因素如血脂、血压、肥胖之间的相关性。方法对柳州市713名干部测量身高、体质量、腰围(WC)、血压,计算体质量指数(BMI),同时检测空服血糖(FBG)、餐后2h血糖(2hPBG)、血总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)等指标,根据1999年WHO糖尿病诊断标准,将受检者分为三组:正常糖耐量(NGT)、糖耐量低减(IGT)、糖尿病(DM),并进行统计学分析。结果①由NGT→IGT→DM,年龄、BMI、WC、SBP、DBP、TG的水平逐渐升高,且IGT和DM组均较NGT组显著升高(P<0.01),HDL-C水平显著降低(P<0.01)。②随着餐后血糖水平的增高,超重/肥胖、中心肥胖、血脂异常及高血压的检出率逐渐增高(P<0.001)。③2hPBG与年龄、BMI、WC、SBP、DBP、TG呈显著正相关(P<0.001),与HDL-C呈显著负相关(P<0.001),经偏相关分析,在控制其它影响因素后,2hPBG仍与WC、年龄、TG、DBP呈显著正相关(P<0.001)。结论餐后高血糖与中心肥胖、高TG、高血压独立相关,常聚集了较多的心血管危险因素,预示着心血管疾病风险性增加,应尽早采取干预措施,预防心血管疾病的发生。
Objective To explore the correlation between postprandial hyperglycemia and cardiovascular risk factors such as blood lipids, blood pressure and obesity. Methods Seven hundred and seventy cadres in Liuzhou city were assessed for height, body mass, waist circumference (WC), blood pressure, body mass index (BMI), meanwhile FBG, 2hPBG, TC ), Triglyceride (TG), high-density lipoprotein cholesterol (HDL-C) and low-density lipoprotein cholesterol (LDL-C) were divided into three groups according to the WHO diagnostic criteria of WHO in 1999: Normal glucose tolerance (NGT), impaired glucose tolerance (IGT), diabetes mellitus (DM), and statistical analysis. Results ① The levels of NGT, IGT, DM, age, BMI, WC, SBP, DBP and TG increased gradually in both IGT and DM groups compared with NGT group (P <0.01) (P <0.01). ② With the increase of postprandial blood glucose level, the prevalence of overweight / obesity, central obesity, dyslipidemia and hypertension were gradually increased (P <0.001). (P <0.001) .2hPBG was positively correlated with age, BMI, WC, SBP, DBP, TG (P <0.001) and had a significant negative correlation with HDL-C (P <0.001) .By partial correlation analysis, after 2hPBG Still with WC, age, TG, DBP was significantly correlated (P <0.001). Conclusion Postprandial hyperglycemia is independently associated with central obesity, high TG and hypertension. It often accumulates more cardiovascular risk factors, which indicates the increased risk of cardiovascular disease. Early interventions should be taken to prevent the occurrence of cardiovascular diseases.