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连续使用地塞米松抑制14天,来测定雄激素过高可能来源。但地塞米松的确实机制仍不明瞭。作者假定地塞米松可能是抑制性激素结合球蛋白的合成或分泌。为了验证这一假说,患多囊卵巢病的14例妇女和3例志愿妇女连续使用地塞米松14天。多囊卵巢组包括肥胖和不肥胖的妇女(±15%为理想体重)。并对血浆中全睾酮、游离睾酮、雄甾烷二酮、硫酸脱氢表雄甾酮、LH、FSH、氢化可的松和性激素结合球蛋白进行放射免疫测定。地塞米松抑制性激素结合球蛋白的水平(P<0.01)。肥胖妇女的性激素结合球蛋白水平低于不肥胖妇女(P<0.01)。所有雄激素均为地塞米松抑制,例外的是使用地塞米松后的雄甾烷二酮水平在14例受试中的6例比给予地塞米松之前明显升高(P>
Continuous use of dexamethasone for 14 days inhibits the possible source of androgen excess. But the exact mechanism of dexamethasone remains unclear. The authors hypothesize that dexamethasone may inhibit the synthesis or secretion of sex hormone-binding globulin. To test this hypothesis, 14 women with polycystic ovary disease and 3 volunteer women received dexamethasone for 14 consecutive days. The polycystic ovary group includes both obese and non-obese women (± 15% of ideal body weight). Radioimmunoassay was performed on plasma total testosterone, free testosterone, androstanedione, dehydroepiandrosterone sulfate, LH, FSH, hydrocortisone, and sex hormone binding globulin. Dexamethasone inhibited the level of sex hormone binding globulin (P <0.01). Obese women sex hormone binding globulin levels were lower than non-obese women (P <0.01). All androgens were dexamethasone with the exception that the level of androstanedione after dexamethasone was significantly higher in 6 of the 14 subjects than before dexamethasone (P>