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目的探讨MUC1、MUC2两种粘蛋白在宫颈鳞状细胞癌中的表达及其临床意义。方法 30例宫颈鳞状细胞癌的组织样本(实验组)和10例轻度慢性宫颈炎的组织标本(对照组),应用免疫组织化学及Western blot技术检测组织内MUC1、MUC2两种粘蛋白在宫颈鳞状细胞癌中的表达。结果 MUC1蛋白在宫颈鳞状细胞癌中的表达明显高于对照组(P<0.05),且浸润深度>3mm的癌组织的表达明显高于浸润深度≤3mm(P<0.05);而与发病人群的年龄、浸润范围、宫颈癌组织的分化及有无淋巴结转移无明显相关性;MUC2蛋白在宫颈鳞状细胞癌中无明显表达。结论 MUC1蛋白与子宫颈鳞状细胞癌的发生发展有关。
Objective To investigate the expression of MUC1 and MUC2 mucin in cervical squamous cell carcinoma and its clinical significance. Methods Tissue specimens from 30 cases of cervical squamous cell carcinoma (experimental group) and 10 cases of mild chronic cervicitis (control group) were collected. Immunohistochemistry and Western blotting were used to detect the expression of MUC1 and MUC2 Cervical squamous cell carcinoma in the expression. Results The expression of MUC1 protein in cervical squamous cell carcinoma was significantly higher than that in the control group (P <0.05), and the expression of MUC1 protein was significantly higher in invasive carcinoma> 3mm than that in infiltrative depth ≤3mm (P <0.05) There was no significant correlation between the age, infiltration range, cervical cancer differentiation and lymph node metastasis. MUC2 protein was not expressed in cervical squamous cell carcinoma. Conclusion MUC1 protein is associated with the occurrence and development of cervical squamous cell carcinoma.