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波吲洛尔(Bopindolol)为一强效β阻滞剂,作用时间极长;它阻滞α_1和α_2受体,具有内在拟交感活性(ISA)。血流动力学双盲研究证明,波吲洛尔或阿替洛尔(选择性β_1阻滞剂、无ISA)治疗的35例原发性高血压,8周降压效果彼此相似。但波吲洛尔使总外周血管阻力下降10.6％,心肌功能无变化;阿替洛尔则使心排血量下降9.7％。说明波吲洛尔的血流动力学比阿替洛尔更有利。降压效果 244例原发性轻、中度高血
Bopindolol is a potent beta-blocker with a very long duration of action; it blocks alpha 1 and alpha 2 receptors and has intrinsic sympathomimetic activity (ISA). Hemodynamic double-blind studies have shown that 35 patients with essential hypertension treated with either bropingllol or atenolol (selective β-blocker, ISA-free), have similar antihypertensive efficacy at 8 weeks. However, BOPP decreased total peripheral vascular resistance by 10.6%, with no change in myocardial function. Atenolol decreased the amount of cardiac output by 9.7%. Binding hemodynamics than atenolol more favorable. Antihypertensive effect of 244 cases of primary mild to moderate high blood